FcγRII-binding Centyrins mediate agonism and antibody-dependent cellular phagocytosis when fused to an anti-OX40 antibody

Immunostimulatory antibodies against the tumor necrosis factor receptors (TNFR) are emerging as promising cancer immunotherapies. The agonism activity of such antibodies depends on crosslinking to Fc gamma RIIB receptor (FcγRIIB) to enable the antibody multimerization that drives TNFR activation. Pr...

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Detalles Bibliográficos
Autores principales: Zhang, Di, Whitaker, Brian, Derebe, Mehabaw G., Chiu, Mark L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916553/
https://www.ncbi.nlm.nih.gov/pubmed/29359992
http://dx.doi.org/10.1080/19420862.2018.1424611

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916553/
https://www.ncbi.nlm.nih.gov/pubmed/29359992
http://dx.doi.org/10.1080/19420862.2018.1424611

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