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Autophagy inhibition improves the cytotoxic effects of receptor tyrosine kinase inhibitors

BACKGROUND: A growing field of evidence suggests the involvement of oncogenic receptor tyrosine kinases (RTKs) in cell transformation. Deregulated activity of RTKs in tumors can determine disease progression and therapeutic responses in several types of cancer, including neuroblastoma (NB). Therefor...

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Detalles Bibliográficos
Autores principales: Aveic, Sanja, Pantile, Marcella, Polo, Pierfrancesco, Sidarovich, Viktoryia, De Mariano, Marilena, Quattrone, Alessandro, Longo, Luca, Tonini, Gian Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916832/
https://www.ncbi.nlm.nih.gov/pubmed/29713246
http://dx.doi.org/10.1186/s12935-018-0557-4