Histone demethylase LSD1 regulates bone mass by controlling WNT7B and BMP2 signaling in osteoblasts

Multiple regulatory mechanisms control osteoblast differentiation and function to ensure unperturbed skeletal formation and remodeling. In this study we identify histone lysine-specific demethylase 1(LSD1/KDM1A) as a key epigenetic regulator of osteoblast differentiation. Knockdown of LSD1 promoted...

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Detalles Bibliográficos
Autores principales: Sun, Jun, Ermann, Joerg, Niu, Ningning, Yan, Guang, Yang, Yang, Shi, Yujiang, Zou, Weiguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916912/
https://www.ncbi.nlm.nih.gov/pubmed/29707403
http://dx.doi.org/10.1038/s41413-018-0015-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916912/
https://www.ncbi.nlm.nih.gov/pubmed/29707403
http://dx.doi.org/10.1038/s41413-018-0015-x

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