Cargando…

A Genome-Wide Linkage Study for Chronic Obstructive Pulmonary Disease in a Dutch Genetic Isolate Identifies Novel Rare Candidate Variants

Chronic obstructive pulmonary disease (COPD) is a complex and heritable disease, associated with multiple genetic variants. Specific familial types of COPD may be explained by rare variants, which have not been widely studied. We aimed to discover rare genetic variants underlying COPD through a geno...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nedeljkovic, Ivana, Terzikhan, Natalie, Vonk, Judith M., van der Plaat, Diana A., Lahousse, Lies, van Diemen, Cleo C., Hobbs, Brian D., Qiao, Dandi, Cho, Michael H., Brusselle, Guy G., Postma, Dirkje S., Boezen, H. M., van Duijn, Cornelia M., Amin, Najaf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916965/ https://www.ncbi.nlm.nih.gov/pubmed/29725345 http://dx.doi.org/10.3389/fgene.2018.00133

Ejemplares similares

Occupational exposure to gases/fumes and mineral dust affect DNA methylation levels of genes regulating expression
por: van der Plaat, Diana A, et al.
Publicado: (2019)

Limited overlap in significant hits between genome-wide association studies on two airflow obstruction definitions in the same population
por: van der Plaat, Diana A., et al.
Publicado: (2019)

DNA methylation is associated with lung function in never smokers
por: de Vries, Maaike, et al.
Publicado: (2019)

Occupational exposure to pesticides is associated with differential DNA methylation
por: van der Plaat, Diana A, et al.
Publicado: (2018)

COPD GWAS variant at 19q13.2 in relation with DNA methylation and gene expression
por: Nedeljkovic, Ivana, et al.
Publicado: (2018)

From blood to lung tissue: effect of cigarette smoke on DNA methylation and lung function
por: de Vries, Maaike, et al.
Publicado: (2018)

ADAM33 Gene Polymorphisms and Mortality. A Prospective Cohort Study
por: Figarska, Sylwia M., et al.
Publicado: (2013)

Decorin and TGF-β(1 )polymorphisms and development of COPD in a general population
por: van Diemen, Cleo C, et al.
Publicado: (2006)

Long-term Air Pollution Exposure, Genome-wide DNA Methylation and Lung Function in the LifeLines Cohort Study
por: de F.C. Lichtenfels, Ana Julia, et al.
Publicado: (2018)

A cross-omics integrative study of metabolic signatures of chronic obstructive pulmonary disease
por: Prokić, Ivana, et al.
Publicado: (2020)

Linkage analysis and whole exome sequencing identify a novel candidate gene in a Dutch multiple sclerosis family
por: Mescheriakova, Julia Y, et al.
Publicado: (2018)

Prevalence and incidence of COPD in smokers and non-smokers: the Rotterdam Study
por: Terzikhan, Natalie, et al.
Publicado: (2016)

Blood eosinophil level and lung function trajectories: cross-sectional and longitudinal studies in European cohorts
por: Mogensen, Ida, et al.
Publicado: (2020)

COPD is associated with an increased risk of peripheral artery disease and mortality
por: Terzikhan, Natalie, et al.
Publicado: (2018)

Genes and pathways underlying susceptibility to impaired lung function in the context of environmental tobacco smoke exposure
por: de Jong, K., et al.
Publicado: (2017)

β(2)-Adrenergic Receptor (ADRB2) Gene Polymorphisms and Risk of COPD Exacerbations: The Rotterdam Study
por: Karimi, Leila, et al.
Publicado: (2019)

Lung Function Impairment and the Risk of Incident Dementia: The Rotterdam Study
por: Xiao, Tian, et al.
Publicado: (2021)

Nicotinic Acetylcholine Receptor Variants Are Related to Smoking Habits, but Not Directly to COPD
por: Budulac, Simona E., et al.
Publicado: (2012)

GST-omega genes interact with environmental tobacco smoke on adult level of lung function
por: de Jong, Kim, et al.
Publicado: (2013)

Adherence to the 2015 Dutch dietary guidelines and risk of non-communicable diseases and mortality in the Rotterdam Study
por: Voortman, Trudy, et al.
Publicado: (2017)

Comparison of cerebral blood flow in subjects with and without chronic obstructive pulmonary disease from the population-based Rotterdam Study
por: Wijnant, Sara R A, et al.
Publicado: (2021)

No association between DNA methylation and COPD in never and current smokers
por: de Vries, Maaike, et al.
Publicado: (2018)

Toll-Like Receptor (TLR2 and TLR4) Polymorphisms and Chronic Obstructive Pulmonary Disease
por: Budulac, Simona E., et al.
Publicado: (2012)

Epigenome-wide association study on diffusing capacity of the lung
por: Terzikhan, Natalie, et al.
Publicado: (2021)

Genetic variation in TIMP1 but not MMPs predict excess FEV(1 )decline in two general population-based cohorts
por: van Diemen, CC, et al.
Publicado: (2011)

Sarcopenia in COPD: a systematic review and meta-analysis
por: Benz, Elizabeth, et al.
Publicado: (2019)

Objective allergy markers and risk of cancer mortality and hospitalization in a large population-based cohort
por: Taghizadeh, Niloofar, et al.
Publicado: (2014)

A Genomic Background Based Method for Association Analysis in Related Individuals
por: Amin, Najaf, et al.
Publicado: (2007)

The Role of Gut Microbiota in Neuropsychiatric Diseases – Creation of An Atlas-Based on Quantified Evidence
por: Bonnechère, Bruno, et al.
Publicado: (2022)

What Are the Key Gut Microbiota Involved in Neurological Diseases? A Systematic Review
por: Bonnechère, Bruno, et al.
Publicado: (2022)

Data linkage of two national databases: Lessons learned from linking the Dutch Arthroplasty Register with the Dutch Foundation for Pharmaceutical Statistics
por: van Brug, Heather E., et al.
Publicado: (2023)

Urokinase plasminogen activator receptor polymorphisms and airway remodelling in asthma
por: Ierodiakonou, Despo, et al.
Publicado: (2016)

Sarcopenia in older people with chronic airway diseases: the Rotterdam study
por: Benz, Elizabeth, et al.
Publicado: (2021)

Acute effects of cigarette smoking on inflammation in healthy intermittent smokers
por: van der Vaart, Hester, et al.
Publicado: (2005)

Effect of β-blockers on the risk of COPD exacerbations according to indication of use: the Rotterdam Study
por: Karimi, Leila, et al.
Publicado: (2021)

Epidemiology and impact of chronic bronchitis in chronic obstructive pulmonary disease
por: Lahousse, Lies, et al.
Publicado: (2017)

Multidrug resistance-associated protein-1 (MRP1) genetic variants, MRP1 protein levels and severity of COPD
por: Budulac, Simona E, et al.
Publicado: (2010)

Serum Immunoglobulins, Pneumonia Risk, and Lung Function in Middle-Aged and Older Individuals: A Population-Based Cohort Study
por: Khan, Samer R., et al.
Publicado: (2022)

Level and course of FEV(1 )in relation to polymorphisms in NFE2L2 and KEAP1 in the general population
por: Siedlinski, Mateusz, et al.
Publicado: (2009)

A Combined Linkage and Exome Sequencing Analysis for Electrocardiogram Parameters in the Erasmus Rucphen Family Study
por: Silva, Claudia T., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_t7pungf2oack4aehotdt7gg5jp