Development of a High-Throughput Flow Cytometry Assay to Monitor Defective Trafficking and Rescue of Long QT2 Mutant hERG Channels

Long QT Syndrome (LQTS) is an acquired or inherited disorder characterized by prolonged QT interval, exertion-triggered arrhythmias, and sudden cardiac death. One of the most prevalent hereditary LQTS subtypes, LQT2, results from loss-of-function mutations in the hERG channel, which conducts I(Kr),...

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Detalles Bibliográficos
Autores principales: Kanner, Scott A., Jain, Ananya, Colecraft, Henry M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917007/
https://www.ncbi.nlm.nih.gov/pubmed/29725305
http://dx.doi.org/10.3389/fphys.2018.00397

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917007/
https://www.ncbi.nlm.nih.gov/pubmed/29725305
http://dx.doi.org/10.3389/fphys.2018.00397

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