Cargando…

Salidroside Promotes the Pathological α-Synuclein Clearance Through Ubiquitin-Proteasome System in SH-SY5Y Cells

Parkinson’s disease (PD) is characterized by the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc) and the presence of Lewy bodies (LBs) in the surviving SNc neurons. LBs formation is caused by the accumulation of α-synuclein (α-syn) or phosphorylated α-syn at serine-129...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Tao, Feng, Yang, Yang, Ruixin, Wu, Leitao, Li, Ruru, Huang, Lu, Yang, Qian, Chen, Jianzong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917065/ https://www.ncbi.nlm.nih.gov/pubmed/29725300 http://dx.doi.org/10.3389/fphar.2018.00377

Ejemplares similares

Salidroside Protects Dopaminergic Neurons by Enhancing PINK1/Parkin-Mediated Mitophagy
por: Li, Ruru, et al.
Publicado: (2019)

Salidroside Protects against MPP+-Induced Neuronal Injury through DJ-1-Nrf2 Antioxidant Pathway
por: Wu, Leitao, et al.
Publicado: (2017)

Salidroside protects SH-SY5Y from pathogenic α-synuclein by promoting cell autophagy via mediation of mTOR/p70S6K signaling
por: Chen, Shasha, et al.
Publicado: (2019)

Salidroside Protects Dopaminergic Neurons by Preserving Complex I Activity via DJ-1/Nrf2-Mediated Antioxidant Pathway
por: Li, Ruru, et al.
Publicado: (2019)

A Matrigel-based 3D construct of SH-SY5Y cells models the α-synuclein pathologies of Parkinson's disease
por: Li, Zhao-Feng, et al.
Publicado: (2022)

Hepcidin Decreases Rotenone-Induced α-Synuclein Accumulation via Autophagy in SH-SY5Y Cells
por: Li, Meiqi, et al.
Publicado: (2020)

Super-resolution imaging reveals α-synuclein seeded aggregation in SH-SY5Y cells
por: Sang, Jason C., et al.
Publicado: (2021)

Ubiquitination Increases Parkin Activity to Promote Autophagic α-Synuclein Clearance
por: Lonskaya, Irina, et al.
Publicado: (2013)

α-Synuclein Decreases the Abundance of Proteasome Subunits and Alters Ubiquitin Conjugates in Yeast
por: Popova, Blagovesta, et al.
Publicado: (2021)

Salidroside Ameliorates Cardiomyocyte Hypertrophy by Upregulating Peroxisome Proliferator-Activated Receptor-α
por: Gao, Hui, et al.
Publicado: (2022)

Neuroprotective effects of genistein on SH-SY5Y cells overexpressing A53T mutant α-synuclein
por: Wu, Huan-Cheng, et al.
Publicado: (2018)

Ndfip1 Prevents Rotenone-Induced Neurotoxicity and Upregulation of α-Synuclein in SH-SY5Y Cells
por: Liu, Xin, et al.
Publicado: (2021)

The Ubiquitin-Proteasome System in Apoptosis and Apoptotic Cell Clearance
por: Yuan, Lei, et al.
Publicado: (2022)

α-Cyperone Attenuates H(2)O(2)-Induced Oxidative Stress and Apoptosis in SH-SY5Y Cells via Activation of Nrf2
por: Huang, Bingxu, et al.
Publicado: (2020)

Proteasome Inhibitors Alter Levels of Intracellular Peptides in HEK293T and SH-SY5Y Cells
por: Dasgupta, Sayani, et al.
Publicado: (2014)

Proteasome impairment by α-synuclein
por: Zondler, Lisa, et al.
Publicado: (2017)

Early-onset impairment of the ubiquitin-proteasome system in dopaminergic neurons caused by α-synuclein
por: McKinnon, Chris, et al.
Publicado: (2020)

α-synuclein strains that cause distinct pathologies differentially inhibit proteasome
por: Suzuki, Genjiro, et al.
Publicado: (2020)

Oxidative Stress Regulated Iron Regulatory Protein IRP2 Through FBXL5-Mediated Ubiquitination-Proteasome Way in SH-SY5Y Cells
por: Jiao, Qian, et al.
Publicado: (2019)

Comparative analysis of in vitro neurotoxicity of methylmercury, mercury, cadmium, and hydrogen peroxide on SH-SY5Y cells
por: SUDO, Kasumi, et al.
Publicado: (2019)

Salidroside Improves Chronic Stress Induced Depressive Symptoms Through Microglial Activation Suppression
por: Fan, Yang, et al.
Publicado: (2021)

Death-associated Protein Kinase 1 Phosphorylates α-Synuclein at Ser129 and Exacerbates Rotenone-induced Toxic Aggregation of α-Synuclein in Dopaminergic SH-SY5Y Cells
por: Shin, Woo Hyun, et al.
Publicado: (2020)

Ellagic Acid Prevents α-Synuclein Aggregation and Protects SH-SY5Y Cells from Aggregated α-Synuclein-Induced Toxicity via Suppression of Apoptosis and Activation of Autophagy
por: Ardah, Mustafa T, et al.
Publicado: (2021)

Therapeutic potential and molecular mechanisms of salidroside in ischemic diseases
por: Han, Jingxuan, et al.
Publicado: (2022)

A novel method for generating glutamatergic SH-SY5Y neuron-like cells utilizing B-27 supplement
por: Martin, Emily-Rose, et al.
Publicado: (2022)

Neuroprotective effect of chondroitin sulfate on SH-SY5Y cells overexpressing wild-type or A53T mutant α-synuclein
por: Ju, Chuanxia, et al.
Publicado: (2017)

The Impairments of α-Synuclein and Mechanistic Target of Rapamycin in Rotenone-Induced SH-SY5Y Cells and Mice Model of Parkinson’s Disease
por: Ramalingam, Mahesh, et al.
Publicado: (2019)

Dopamine Homeostasis Imbalance and Dopamine Receptors-Mediated AC/cAMP/PKA Pathway Activation are Involved in Aconitine-Induced Neurological Impairment in Zebrafish and SH-SY5Y Cells
por: Zhou, Jie, et al.
Publicado: (2022)

Effects of Different Opioid Drugs on Oxidative Status and Proteasome Activity in SH-SY5Y Cells
por: Rullo, Laura, et al.
Publicado: (2022)

Neuroprotective Effects of Salidroside in the MPTP Mouse Model of Parkinson's Disease: Involvement of the PI3K/Akt/GSK3β Pathway
por: Zhang, Wei, et al.
Publicado: (2016)

Dopamine Cytotoxicity Involves Both Oxidative and Nonoxidative Pathways in SH-SY5Y Cells: Potential Role of Alpha-Synuclein Overexpression and Proteasomal Inhibition in the Etiopathogenesis of Parkinson's Disease
por: Banerjee, Kalpita, et al.
Publicado: (2014)

Corrigendum: Dopamine homeostasis imbalance and dopamine receptors-mediated AC/cAMP/PKA pathway activation are involved in aconitine-induced neurological impairment in zebrafish and SH-SY5Y cells
por: Zhou, Jie, et al.
Publicado: (2023)

Loss-of-Function Piezo1 Mutations Display Altered Stability Driven by Ubiquitination and Proteasomal Degradation
por: Zhou, Zijing, et al.
Publicado: (2021)

Ubiquitin-Proteasome-Collagen (CUP) Pathway in Preterm Premature Rupture of Fetal Membranes
por: Zhao, Xinliang, et al.
Publicado: (2017)

Carnosic Acid Alleviates Levodopa-Induced Dyskinesia and Cell Death in 6-Hydroxydopamine-lesioned Rats and in SH-SY5Y Cells
por: Lai, Chun-Yi, et al.
Publicado: (2021)

Skeletal Muscle Atrophy Was Alleviated by Salidroside Through Suppressing Oxidative Stress and Inflammation During Denervation
por: Huang, Ziwei, et al.
Publicado: (2019)

Proteomic Study of a Parkinson's Disease Model of Undifferentiated SH-SY5Y Cells Induced by a Proteasome Inhibitor
por: Jiang, Huiyi, et al.
Publicado: (2019)

Tibetan medicine salidroside improves host anti-mycobacterial response by boosting inflammatory cytokine production in zebrafish
por: He, Shumei, et al.
Publicado: (2022)

Observation of α-Synuclein Preformed Fibrils Interacting with SH-SY5Y Neuroblastoma Cell Membranes Using Scanning Ion Conductance Microscopy
por: Feng, Christina, et al.
Publicado: (2022)

Ubiquitin-proteasome system-based signature to predict the prognosis and drug sensitivity of hepatocellular carcinoma
por: Zhang, Jianxiang, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_3d8gq7n9914n692qsba93fdls7