USP9X Limits Mitotic Checkpoint Complex Turnover to Strengthen the Spindle Assembly Checkpoint and Guard against Chromosomal Instability

Faithful chromosome segregation during mitosis depends on the spindle assembly checkpoint (SAC), which delays progression through mitosis until every chromosome has stably attached to spindle microtubules via the kinetochore. We show here that the deubiquitinase USP9X strengthens the SAC by antagoni...

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Detalles Bibliográficos
Autores principales: Skowyra, Agnieszka, Allan, Lindsey A., Saurin, Adrian T., Clarke, Paul R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917450/
https://www.ncbi.nlm.nih.gov/pubmed/29669289
http://dx.doi.org/10.1016/j.celrep.2018.03.100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917450/
https://www.ncbi.nlm.nih.gov/pubmed/29669289
http://dx.doi.org/10.1016/j.celrep.2018.03.100

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