Mechanism of Methotrexate‐sensitivity of Choriocarcinoma Cells in Culture

Four cell lines established from choriocarcinoma were compared for sensitivity to methotrexate (MTX). In this paper, we have compared the relative gene copy number of dihydrofolate reductase (DHFR), the target enzyme of methotrexate (MTX), in order to clarify whether or not amplification of the gene...

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Detalles Bibliográficos
Autores principales: Indue, Takami, Nagura, Eiichi, Toyoda, Tetsuya, Ishizuka, Takao, Gotoh, Setsuko, Kawashima, Kohei, Tomoda, Yutaka, Nagai, Yoshiyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1988
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917478/
https://www.ncbi.nlm.nih.gov/pubmed/2836349
http://dx.doi.org/10.1111/j.1349-7006.1988.tb01604.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917478/
https://www.ncbi.nlm.nih.gov/pubmed/2836349
http://dx.doi.org/10.1111/j.1349-7006.1988.tb01604.x

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