A POSSIBLE ROLE OF GLUCOCORTICOIDS: AN INTRINSIC INHIBITOR OF THE CYTOTOXIC ACTIVITY OF TUMOR NECROSIS FACTOR

The cytotoxic activity of tumor necrosis factor (TNF) against L929 fibroblasts in vivo was non‐competitively inhibited by physiological concentrations of glucocorticoids such as hydrocortisone (10(‐7)M), corticosterone (5 × 10(‐8)M) and dexamethasone (5 × 10(‐9)M). The inhibition was abolished by th...

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Detalles Bibliográficos
Autores principales: Abe, Shigeru, Yamamoto, Takahiko, Iihara, Seiji, Yamazaki, Masatoshi, Mizuno, Den'ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1988
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917485/
https://www.ncbi.nlm.nih.gov/pubmed/3131280
http://dx.doi.org/10.1111/j.1349-7006.1988.tb01591.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917485/
https://www.ncbi.nlm.nih.gov/pubmed/3131280
http://dx.doi.org/10.1111/j.1349-7006.1988.tb01591.x

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