Demethylation by 5‐Azacytidine Results in the Expression of Hepatitis B Virus Surface Antigen in Transgenic Mice

In 14p3HB transgenic mice, which carry three tandem copies of hepatitis B virus (HBV) DNA, the HBV DNA was significantly methylated and no viral proteins were produced. To analyze the causal relationship between hypermethylation and gene inactivity, 5‐azacytidine was injected into the mice to demeth...

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Detalles Bibliográficos
Autores principales: Araki, Kimi, Miyazaki, Jun‐ichi, Tsurimoto, Toshiki, Inomoto, Takeaki, Iwanaga, Tomohisa, Matsubara, Kenichi, Yamamura, Ken‐ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1989
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917734/
https://www.ncbi.nlm.nih.gov/pubmed/2473052
http://dx.doi.org/10.1111/j.1349-7006.1989.tb02308.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917734/
https://www.ncbi.nlm.nih.gov/pubmed/2473052
http://dx.doi.org/10.1111/j.1349-7006.1989.tb02308.x

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