Perturbed autophagy and DNA repair converge to promote neurodegeneration in amyotrophic lateral sclerosis and dementia

Maintaining genomic stability constitutes a major challenge facing cells. DNA breaks can arise from direct oxidative damage to the DNA backbone, the inappropriate activities of endogenous enzymes such as DNA topoisomerases, or due to transcriptionally-derived RNA/DNA hybrids (R-loops). The progressi...

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Detalles Bibliográficos
Autores principales: Walker, Callum, El-Khamisy, Sherif F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Review Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917746/
https://www.ncbi.nlm.nih.gov/pubmed/29584802
http://dx.doi.org/10.1093/brain/awy076

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917746/
https://www.ncbi.nlm.nih.gov/pubmed/29584802
http://dx.doi.org/10.1093/brain/awy076

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