Carcinogenicity of 2‐Amino‐3‐methylimidazo[4,5‐f]quinoline in Nonhuman Primates: Induction of Tumors in Three Macaques

The carcinogenic potential of 2‐amino‐3‐methylimidazo[4,5f]quinoline (IQ) was evaluated in cynomolgus monkeys. Monkeys received IQ, beginning at the age of one year, at doses of 10 or 20 mg/kg by gavage. Thus far, IQ has induced hepatocellular carcinoma in three monkeys with a latent period of 27 to...

Descripción completa

Detalles Bibliográficos
Autores principales: Adamson, Richard H., Thorgeirsson, Unnur P., Snyderwine, Elizabeth G., Thorgeirsson, Snorri S., Reeves, Jeanette, Dalgard, Dan W., Takayama, Shozo, Sugimura, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1990
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917955/
https://www.ncbi.nlm.nih.gov/pubmed/1691162
http://dx.doi.org/10.1111/j.1349-7006.1990.tb02500.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917955/
https://www.ncbi.nlm.nih.gov/pubmed/1691162
http://dx.doi.org/10.1111/j.1349-7006.1990.tb02500.x

Ejemplares similares