Carcinogenicity of 2‐Amino‐3‐methylimidazo[4,5‐f]quinoline in Nonhuman Primates: Induction of Tumors in Three Macaques

The carcinogenic potential of 2‐amino‐3‐methylimidazo[4,5f]quinoline (IQ) was evaluated in cynomolgus monkeys. Monkeys received IQ, beginning at the age of one year, at doses of 10 or 20 mg/kg by gavage. Thus far, IQ has induced hepatocellular carcinoma in three monkeys with a latent period of 27 to...

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Autores principales: Adamson, Richard H., Thorgeirsson, Unnur P., Snyderwine, Elizabeth G., Thorgeirsson, Snorri S., Reeves, Jeanette, Dalgard, Dan W., Takayama, Shozo, Sugimura, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1990
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917955/
https://www.ncbi.nlm.nih.gov/pubmed/1691162
http://dx.doi.org/10.1111/j.1349-7006.1990.tb02500.x
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author Adamson, Richard H.
Thorgeirsson, Unnur P.
Snyderwine, Elizabeth G.
Thorgeirsson, Snorri S.
Reeves, Jeanette
Dalgard, Dan W.
Takayama, Shozo
Sugimura, Takashi
author_facet Adamson, Richard H.
Thorgeirsson, Unnur P.
Snyderwine, Elizabeth G.
Thorgeirsson, Snorri S.
Reeves, Jeanette
Dalgard, Dan W.
Takayama, Shozo
Sugimura, Takashi
author_sort Adamson, Richard H.
collection PubMed
description The carcinogenic potential of 2‐amino‐3‐methylimidazo[4,5f]quinoline (IQ) was evaluated in cynomolgus monkeys. Monkeys received IQ, beginning at the age of one year, at doses of 10 or 20 mg/kg by gavage. Thus far, IQ has induced hepatocellular carcinoma in three monkeys with a latent period of 27 to 37 months. Metastases to the lung occurred in two of the three monkeys. Microscopically, the hepatocellular carcinoma in all three cases demonstrated a trabecular pattern. These data demonstrate that IQ is a potent carcinogen in nonhuman primates and support the idea that it is a potential carcinogen for humans.
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spelling pubmed-59179552018-05-11 Carcinogenicity of 2‐Amino‐3‐methylimidazo[4,5‐f]quinoline in Nonhuman Primates: Induction of Tumors in Three Macaques Adamson, Richard H. Thorgeirsson, Unnur P. Snyderwine, Elizabeth G. Thorgeirsson, Snorri S. Reeves, Jeanette Dalgard, Dan W. Takayama, Shozo Sugimura, Takashi Jpn J Cancer Res Article The carcinogenic potential of 2‐amino‐3‐methylimidazo[4,5f]quinoline (IQ) was evaluated in cynomolgus monkeys. Monkeys received IQ, beginning at the age of one year, at doses of 10 or 20 mg/kg by gavage. Thus far, IQ has induced hepatocellular carcinoma in three monkeys with a latent period of 27 to 37 months. Metastases to the lung occurred in two of the three monkeys. Microscopically, the hepatocellular carcinoma in all three cases demonstrated a trabecular pattern. These data demonstrate that IQ is a potent carcinogen in nonhuman primates and support the idea that it is a potential carcinogen for humans. Blackwell Publishing Ltd 1990-01 /pmc/articles/PMC5917955/ /pubmed/1691162 http://dx.doi.org/10.1111/j.1349-7006.1990.tb02500.x Text en
spellingShingle Article
Adamson, Richard H.
Thorgeirsson, Unnur P.
Snyderwine, Elizabeth G.
Thorgeirsson, Snorri S.
Reeves, Jeanette
Dalgard, Dan W.
Takayama, Shozo
Sugimura, Takashi
Carcinogenicity of 2‐Amino‐3‐methylimidazo[4,5‐f]quinoline in Nonhuman Primates: Induction of Tumors in Three Macaques
title Carcinogenicity of 2‐Amino‐3‐methylimidazo[4,5‐f]quinoline in Nonhuman Primates: Induction of Tumors in Three Macaques
title_full Carcinogenicity of 2‐Amino‐3‐methylimidazo[4,5‐f]quinoline in Nonhuman Primates: Induction of Tumors in Three Macaques
title_fullStr Carcinogenicity of 2‐Amino‐3‐methylimidazo[4,5‐f]quinoline in Nonhuman Primates: Induction of Tumors in Three Macaques
title_full_unstemmed Carcinogenicity of 2‐Amino‐3‐methylimidazo[4,5‐f]quinoline in Nonhuman Primates: Induction of Tumors in Three Macaques
title_short Carcinogenicity of 2‐Amino‐3‐methylimidazo[4,5‐f]quinoline in Nonhuman Primates: Induction of Tumors in Three Macaques
title_sort carcinogenicity of 2‐amino‐3‐methylimidazo[4,5‐f]quinoline in nonhuman primates: induction of tumors in three macaques
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917955/
https://www.ncbi.nlm.nih.gov/pubmed/1691162
http://dx.doi.org/10.1111/j.1349-7006.1990.tb02500.x
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