Methotrexate Cytotoxicity as Related to Irreversible S Phase Arrest in Mouse L1210 Leukemia Cells

The association between cytotoxicity and cell cycle perturbation caused by methotrexate (MTX) was investigated in mouse L1210 leukemia cells by flow cytometric bromodeoxyuridine/DNA assay. In the range of concentrations of MTX from 10(‐7)M to 10(‐6)M, in vitro exposure to the drug for 6 h caused a d...

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Detalles Bibliográficos
Autores principales: Tsurusawa, Masahito, Niwa, Makoto, Katano, Naoyuki, Fujimoto, Takeo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1990
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917961/
https://www.ncbi.nlm.nih.gov/pubmed/2108951
http://dx.doi.org/10.1111/j.1349-7006.1990.tb02511.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917961/
https://www.ncbi.nlm.nih.gov/pubmed/2108951
http://dx.doi.org/10.1111/j.1349-7006.1990.tb02511.x

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