Cargando…

Mutational Activation of H‐ras and K‐ras Genes Is Absent in N‐Nitroso‐N‐methylurea‐induced Liver Tumors in Rats

We examined mutational activation of H‐ and K‐ras genes in hyperplastic nodules and hepatocellular carcinomas induced by N‐nitroso‐N‐methylurea or diethylnitrosamine using the polymerase chain reaction, followed by dot‐blot hybridization. No mutational activation was detected in these hepatic lesion...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sakai, Hirotsuka, Ogawa, Katsuhiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 1990
Materias:	Rapid Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918065/ https://www.ncbi.nlm.nih.gov/pubmed/2116389 http://dx.doi.org/10.1111/j.1349-7006.1990.tb02587.x

Ejemplares similares

Proceedings: Immunosuppressive activity of N-nitroso-N-methylurea (NMU) and dimethylnitrosamine (DMN).
por: Waynforth, H. B., et al.
Publicado: (1974)

Chemoprevention of N‐Nitroso‐N‐methylurea‐induced Rat Mammary Carcinogenesis by Soy Foods or Biochanin A
por: Gotoh, Takahiko, et al.
Publicado: (1998)

Chemoprevention of N‐Nitroso‐N‐methylurea‐induced Rat Mammary Cancer by Miso and Tamoxifen, Alone and in Combination
por: Gotoh, Takahiko, et al.
Publicado: (1998)

The Effect of N-Nitroso-N-Methylurea and N-Dimethylnitrosamine on Cell Mediated and Humoral Immune Responses in Rats and Mice
por: Waynforth, H. B., et al.
Publicado: (1974)

Low Incidence of Point Mutation of c‐Ki‐ras and N‐ras Oncogenes in Human Hepatocellular Carcinoma
por: Tsuda, Hitoshi, et al.
Publicado: (1989)

Efficacy of Quercetin-Sensitized Cisplatin against N-Nitroso-N-Methylurea Induced Testicular Carcinogenesis in Wistar Rats
por: El-Diasty, Hend HGM, et al.
Publicado: (2021)

Prolactin, TNF alpha and nitric oxide expression in nitroso-N-methylurea-induced-mammary tumours
por: Vegh, Irene, et al.
Publicado: (2007)

Protective effect of Chuquiraga spinosa Lessing associated with simvastatin on N-Nitroso-N-methylurea (NMU)-induced prostate cancer in rats
por: Arroyo-Acevedo, Jorge Luis, et al.
Publicado: (2019)

Genotoxic Effects of Aluminum Chloride and Their Relationship with N-Nitroso-N-Methylurea (NMU)-Induced Breast Cancer in Sprague Dawley Rats
por: García-Alegría, Alejandro Monserrat, et al.
Publicado: (2020)

Mutations of N‐ras Oncogene in Myelodysplastic Syndromes and Lcukemias Detected by Polymerase Chain Reaction
por: Mano, Hiroyuki, et al.
Publicado: (1989)

Absence of ras Family Point Mutations at Codons 12, 13 and 61 in N‐Ethyl‐N‐hydroxyethylnitrosamine‐ or N‐Nitrosomorpholine‐induced Renal Cell Tumors in Rats
por: Matsumoto, Kazuyuki, et al.
Publicado: (1992)

High Expression of Cyclin D1 and p21 in N-Nitroso-N-Methylurea-Induced Breast Cancer in Wistar Albino Female Rats
por: Ashrafi, Mahboobeh, et al.
Publicado: (2012)

Genotypic Differentiation of Intrahepatically Transplanted Hyperplastic Nodule Cells of Analbuminemic and Normal Rat Origin by Polymerase Chain Reaction
por: Nishikawa, Yuji, et al.
Publicado: (1990)

The roles of age at treatment and dose in carcinogenesis in C3Hf/Dp mice with a single administration of N-nitroso-N-methylurea.
por: Terracini, B., et al.
Publicado: (1976)

Ki‐ras Activation in Pancreatic Carcinomas of Syrian Hamsters Induced by N‐Nitrosobis(2‐hydroxypropyl)amine
por: Ushijima, Toshikazu, et al.
Publicado: (1991)

Effects of Lactofermented Beetroot Juice Alone or with N-nitroso-N-methylurea on Selected Metabolic Parameters, Composition of the Microbiota Adhering to the Gut Epithelium and Antioxidant Status of Rats
por: Klewicka, Elżbieta, et al.
Publicado: (2015)

In vivo Comparative Studies on Antigenotoxicity of Date Palm (Phoenix Dactylifera L.) Pits Extract Against DNA Damage Induced by N-Nitroso-N-methylurea in Mice
por: Diab, K. A. S., et al.
Publicado: (2012)

Altered expression of Bcl-2, c-Myc, H-Ras, K-Ras, and N-Ras does not influence the course of mycosis fungoides
por: Maj, Joanna, et al.
Publicado: (2013)

Molecular Analysis of Oncogenes, ras Family Genes (N‐ras, K‐ras, H‐ras), myc Family Genes (c‐myc, N‐myc) and mdm2 in Natural Killer Cell Neoplasms
por: Sugimoto, Kei‐ji, et al.
Publicado: (2002)

Comparison of K-Ras and N-Ras Mutagenic Hot Spots for UVC Damage
por: Nair, Sindhu G., et al.
Publicado: (2019)

Higher Frequency of Point Mutations in the c‐K‐ras2 Gene in Human Colorectal Adenomas with Severe Atypia than in Carcinomas
por: Ando, Masayuki, et al.
Publicado: (1991)

K‐ras Gene Mutation in Early Ductal Lesions Induced in a Rapid Production Model for Pancreatic Carcinomas in Syrian Hamsters
por: Tsutsumi, Masahiro, et al.
Publicado: (1993)

Mutant K-Ras in Pancreatic Cancer: An Insight on the Role of Wild-Type N-Ras and K-Ras-Dependent Cell Cycle Regulation
por: Ferguson, Robert, et al.
Publicado: (2023)

H‐ras p21 AND PEANUT LECTIN IMMUNOREACTIVITY OF HYPERPLASTIC, PRENEOPLASTIC AND NEOPLASTIC URINARY BLADDER LESIONS IN RATS
por: Ward, Jerrold M., et al.
Publicado: (1988)

Increased Expression of ras Genes in Non‐Hodgkin's Lymphomas Is not Associated with Oncogenic Activation of Those Genes by Point Mutation
por: Hamatani, Kiyohiro, et al.
Publicado: (1989)

Neuroblastoma RAS viral oncogene homolog (N-RAS) deficiency aggravates liver injury and fibrosis
por: Zheng, Kang, et al.
Publicado: (2023)

VPS35 binds farnesylated N-Ras in the cytosol to regulate N-Ras trafficking
por: Zhou, Mo, et al.
Publicado: (2016)

MEK targeting in N-RAS mutated metastatic melanoma
por: Thumar, Jaykumar, et al.
Publicado: (2014)

Transformation of NIH3T3 Cells with Synthetic c‐Ha‐ras Genes
por: Kamiya, Hiroyuki, et al.
Publicado: (1989)

The Distinct Conformational Dynamics of K-Ras and H-Ras A59G
por: Lukman, Suryani, et al.
Publicado: (2010)

PGA(1)-induced apoptosis involves specific activation of H-Ras and N-Ras in cellular endomembranes
por: Anta, B, et al.
Publicado: (2016)

Frequency and Types of Point Mutation at the 12th Codon of the c‐Ki‐ras Gene Found in Pancreatic Cancers from Japanese Patients
por: Mariyama, Mariko, et al.
Publicado: (1989)

Gastro-intestinal tumours in rats and mice following various routes of administration of N-methyl-N-nitroso-N'-nitroguanidine and N-ethyl-N-nitroso-N'-nitroguanidine.
por: Schoental, R., et al.
Publicado: (1969)

RAS Mutations and Oncogenesis: Not all RAS Mutations are Created Equally
por: Miller, Mark Steven, et al.
Publicado: (2012)

Specific contributions of H-Ras and N-Ras GTPases to T-lymphocyte oxidative stress and integrin-dependent retention in rheumatoid arthritis
por: Remans, PHJ, et al.
Publicado: (2005)

In vitro Progression‐associated c‐H‐ras Activation in Neoplastic Hepatocyte Lines Established from SV40‐T Antigen Gene‐harboring Transgenic Mice
por: Li, Hong, et al.
Publicado: (1991)

Overexpression of DA41 in v‐Ha‐ras‐3Y1 Cells Causes Growth Suppression
por: Ozaki, Toshinori, et al.
Publicado: (2000)

Killer K-Ras
por: Powell, Kendall
Publicado: (2006)

K-RAS Is…Complicated
por: Clark, Geoffrey J.
Publicado: (2023)

Environmental Aspects of N-nitroso Compounds
por: Swann, P. F.
Publicado: (1979)

Cannot write session to /tmp/vufind_sessions/sess_r9269ovkn68ioskjj11j53lur0