Synergistic Effect of Cyclosporin A and Verapamil in Overcoming Vincristine Resistance of Multidrug‐resistant Cultured Human Leukemia Cells

Reversal of vincristine (VCR) resistance by cyclosporin A (CyA) or the combination of CyA and verapamil (VER) was investigated by using four P‐glycoprotein (P‐gp)‐associated human multidrug‐resistant (MDR) cell lines (K562/ADM, KYO‐1, HEL and CMK). Drug sensitivity was expressed as 50% inhibitory co...

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Detalles Bibliográficos
Autores principales: Ishida, Yasushi, Shimada, Yasuhiro, Shimoyama, Masanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1990
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918095/
https://www.ncbi.nlm.nih.gov/pubmed/2118896
http://dx.doi.org/10.1111/j.1349-7006.1990.tb02653.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918095/
https://www.ncbi.nlm.nih.gov/pubmed/2118896
http://dx.doi.org/10.1111/j.1349-7006.1990.tb02653.x

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