A Deletion Mutation within the Ligand Binding Domain Is Responsible for Activation of Epidermal Growth Factor Receptor Gene in Human Brain Tumors

Two transplantable cell lines of human glioblastoma multiforme GL‐3 and GL‐5 carried an amplification and overexpression of structurally altered epidermal growth factor (EGF) receptor gene: the 140 kilodalton EGF receptors in these cases exhibited a constitutively expressed tyrosine kinase activity...

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Detalles Bibliográficos
Autores principales: Yamazaki, Hitoshi, Ohba, Yoshito, Tamaoki, Norikazu, Shibuya, Masabumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1990
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918101/
https://www.ncbi.nlm.nih.gov/pubmed/2168866
http://dx.doi.org/10.1111/j.1349-7006.1990.tb02644.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918101/
https://www.ncbi.nlm.nih.gov/pubmed/2168866
http://dx.doi.org/10.1111/j.1349-7006.1990.tb02644.x

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