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Topical application of aminoglycoside antibiotics enhances host resistance to viral infections in a microbiota-independent manner

Antibiotics are widely used to treat infections in humans. However, the impact of antibiotic use on host cells is understudied. Here we identify an antiviral effect of commonly used aminoglycoside antibiotics. We show that topical mucosal application of aminoglycosides prophylactically increased hos...

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Detalles Bibliográficos
Autores principales: Gopinath, Smita, Kim, Myoungjoo V., Rakib, Tasfia, Wong, Patrick W., van Zandt, Michael, Barry, Natasha A., Kaisho, Tsuneyasu, Goodman, Andrew L., Iwasaki, Akiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918160/
https://www.ncbi.nlm.nih.gov/pubmed/29632368
http://dx.doi.org/10.1038/s41564-018-0138-2