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Enhancing Potential of 6 Different Carcinogens on Multi‐organ Tumorigenesis after Initial Treatment with N‐Methyl‐N‐nitrosourea in Rats

The advantages of applying a whole‐body concept to the assessment of carcinogenic potential of compounds in a two‐stage model after initiation by N‐methyl‐N‐nitrosourea (MNU) were investigated. Male, 6‐week‐old F344 rats were injected with MNU (20 mg/kg, i. p.) twice a week for 4 weeks and they then...

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Detalles Bibliográficos
Autores principales:	Uwagawa, Satoshi, Tsuda, Hiroyuki, Inoue, Tadashi, Tagawa, Yoshiaki, Aoki, Toyohiko, Kagawa, Masataka, Ogiso, Tadashi, Ito, Nobuyuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 1991
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918354/ https://www.ncbi.nlm.nih.gov/pubmed/1778764 http://dx.doi.org/10.1111/j.1349-7006.1991.tb01812.x

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