Cargando…

Enhancing Potential of 6 Different Carcinogens on Multi‐organ Tumorigenesis after Initial Treatment with N‐Methyl‐N‐nitrosourea in Rats

The advantages of applying a whole‐body concept to the assessment of carcinogenic potential of compounds in a two‐stage model after initiation by N‐methyl‐N‐nitrosourea (MNU) were investigated. Male, 6‐week‐old F344 rats were injected with MNU (20 mg/kg, i. p.) twice a week for 4 weeks and they then...

Descripción completa

Detalles Bibliográficos
Autores principales:	Uwagawa, Satoshi, Tsuda, Hiroyuki, Inoue, Tadashi, Tagawa, Yoshiaki, Aoki, Toyohiko, Kagawa, Masataka, Ogiso, Tadashi, Ito, Nobuyuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 1991
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918354/ https://www.ncbi.nlm.nih.gov/pubmed/1778764 http://dx.doi.org/10.1111/j.1349-7006.1991.tb01812.x

Ejemplares similares

The multipotential carcinogenic action of N-ethyl-N-nitrosourea administered neonatally to mice.
por: Searle, C. E., et al.
Publicado: (1976)

Proceedings: Strain differences in the carcinogenic action of N-ethyl-N-nitrosourea (ENU) in mice.
por: Searle, C. E., et al.
Publicado: (1974)

Modifying Effects of Various Chemicals on Tumor Development in a Rat Wide‐spectrum Organ Carcinogenesis Model
por: Uwagawa, Satoshi, et al.
Publicado: (1992)

Dose‐dependent Induction of Liver and Thyroid Neoplastic Lesions by Short‐term Administration of 2‐Amino‐3‐methylimidazo[4,5‐f]quinoline Combined with Partial Hepatectomy Followed by Phenobarbital or Low Dose 3′‐Methyl‐4‐dimethylaminoazobenzene Promotion
por: Tsuda, Hiroyuki, et al.
Publicado: (1988)

Effects of Modifying Agents on Conformity of Enzyme Phenotype and Proliferative Potential in Focal Preneoplastic and Neoplastic Liver Cell Lesions in Rats
por: Tsuda, Hiroyuki, et al.
Publicado: (1992)

Short-term carcinogenicity study of N-methyl-N-nitrosourea in FVB-Trp53 heterozygous mice
por: Kim, Na-Won, et al.
Publicado: (2023)

Influence of Aging on Multi‐organ Carcinogenesis in Rats Induced by N‐Methyl‐N‐nitrosourea
por: Mizoguchi, Masae, et al.
Publicado: (1993)

Induction of Adenocarcinomas in the Glandular Stomach of BALB/c Mice Treated with N‐Methyl‐N‐nitrosourea
por: Tatematsu, Masae, et al.
Publicado: (1992)

Antimutagenic components in Spatholobus suberectus Dunn against N-methyl-N-nitrosourea
por: Inami, Keiko, et al.
Publicado: (2019)

Inhibition of N-methyl-N-nitrosourea-induced gastric tumorigenesis by Liuwei Dihuang Pill in db/db mice
por: Zhuang, Shan, et al.
Publicado: (2017)

Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea
por: Li, Zhiguang, et al.
Publicado: (2010)

Isolation and characterization of antimutagenic components of Glycyrrhiza aspera against N-methyl-N-nitrosourea
por: Inami, Keiko, et al.
Publicado: (2017)

Elevated Serum Growth Hormone Accelerates Gastric Tumorigenesis in F344 Rats after Treatment with N‐Methyl‐N‐nitrosourea in Their Drinking Water
por: Watanabe, Hiromitsu, et al.
Publicado: (1995)

Effects of Phenobarbital and Carbazole on Carcinogenesis of the Lung, Thyroid, Kidney, and Bladder of Rats Pretreated with N‐Bis(2‐hydroxypropyl)nitrosamine
por: Shirai, Tomoyuki, et al.
Publicado: (1988)

N,N’-Bis(2-chloroethyl)-N-nitrosourea (BCNU)-induced Apoptosis of Neural Progenitor Cells in the Developing Fetal Rat Brain
por: Yamaguchi, Tsuyoshi, et al.
Publicado: (2010)

Peroxidative metabolism of carcinogenic N-arylhydroxamic acids: implications for tumorigenesis.
por: Malejka-Giganti, D, et al.
Publicado: (1994)

Dose‐dependent Promoting Effects of Catechol on Glandular Stomach Carcinogenesis in BALB/c Mice Initiated with N‐Methyl‐N‐nitrosourea
por: Kobayashi, Kiyoshi, et al.
Publicado: (1997)

Studies on N-Ethyl-N-nitrosourea Mutagenesis in BALB/c Mice
por: Cho, Kyu-Hyuk, et al.
Publicado: (2008)

Enhancing Effects of Estrogens on Endometrial Carcinogenesis Initiated by N‐Methyl‐N‐nitrosourea in ICR Mice
por: Niwa, Kenji, et al.
Publicado: (1993)

4-Hydroxyandrostenedione in the prophylaxis of N-methyl-N-nitrosourea induced mammary tumourigenesis.
por: Coombes, R. C., et al.
Publicado: (1991)

Proceedings: Toxic effect of N-methyl-N-nitrosourea on normal and transformed cells.
por: Wilkinson, R., et al.
Publicado: (1974)

N -Ethyl- N -Nitrosourea Induces Retinal Photoreceptor Damage in Adult Rats
por: Yoshizawa, Katsuhiko, et al.
Publicado: (2012)

Nimodipine inhibits N-methyl-N-nitrosourea-induced retinalphotoreceptor apoptosis in vivo
por: Wang, Dan, et al.
Publicado: (2013)

Nimodipine rescues N-methyl-N-nitrosourea-induced retinal degeneration in rats
por: Wang, Dan, et al.
Publicado: (2013)

Demonstration of ras and p53 Gene Mutations in Carcinomas in the Forestomach and Intestine and Soft Tissue Sarcomas Induced by N‐Methyl‐N‐nitrosourea in the Rat
por: Matsumoto, Kazuyuki, et al.
Publicado: (1997)

Lack of Carcinogenicity of Quercetin in F344/DuCrj Rats
por: Ito, Nobuyuki, et al.
Publicado: (1989)

Earlier Helicobacter pylori Infection Increases the Risk for the N‐Methyl‐N‐nitrosourea‐induced Stomach Carcinogenesis in Mongolian Gerbils
por: Cao, Xueyuan, et al.
Publicado: (2002)

A high protein moderate carbohydrate diet fed at discrete meals reduces early progression of N-methyl-N-nitrosourea-induced breast tumorigenesis in rats
por: Moulton, Christopher J, et al.
Publicado: (2010)

Lack of Carcinogenicity of 2‐Amino‐3,8‐dimethylimidazo[4,5‐f]quinoxaline (MeIQx) in Cynomolgus Monkeys
por: Ogawa, Kumiko, et al.
Publicado: (1999)

Intraluminal Epidermal Growth Factor Affects Growth of N‐Methyl‐N‐nitrosourea‐initiated Rat Bladder Carcinoma
por: Kawai, Koji, et al.
Publicado: (1995)

Induction of bladder cancer in rats by fractionated intravesicular doses of N-methyl-N-nitrosourea.
por: Severs, N. J., et al.
Publicado: (1982)

Proceedings: Syncarcinogenesis with n-methyl N-nitrosourea (MNU) and cyclamate in rat urinary bladder.
por: Chowaniec, J., et al.
Publicado: (1974)

Susceptibility to N-methyl-N-nitrosourea-induced retinal degeneration in different rat strains
por: Emoto, Yuko, et al.
Publicado: (2015)

The temporal topography of the N-Methyl- N-nitrosourea induced photoreceptor degeneration in mouse retina
por: Tao, Ye, et al.
Publicado: (2015)

Genetic Regulation of Development of Thymic Lymphomas Induced by N‐Propyl‐N‐nitrosourea in the Rat
por: Ogiu, Toshiaki, et al.
Publicado: (1995)

Development of Animal Models for Lens and Corneal Diseases Using N-Methyl-N-Nitrosourea
por: Qu, Yingxin, et al.
Publicado: (2020)

Studies on the Small Body Size Mouse Developed by Mutagen N-Ethyl-N-nitrosourea
por: Zhang, QianKun, et al.
Publicado: (2008)

Mutational Analysis of N-Ethyl-N-Nitrosourea (ENU) in the Fission Yeast Schizosaccharomyces pombe
por: Hoyos-Manchado, Rafael, et al.
Publicado: (2020)

Induction of Glandular Stomach Cancers in Helicobacter pylori‐sensitive Mongolian Gerbils Treated with N‐Methyl‐N‐nitrosourea and N‐Methyl‐N′‐nitro‐N‐nitrosoguanidine in Drinking Water
por: Tatematsu, Masae, et al.
Publicado: (1998)

Inhibition of Mammary Tumors by Pretreatment with 17β‐Estradiol in F344 Rats Induced with N‐Methyl‐N‐nitrosourea
por: Ito, Akihiro, et al.
Publicado: (1994)

Cannot write session to /tmp/vufind_sessions/sess_s6gbof99n7omqn2qgop66vcqr2