Higher Frequency of Point Mutations in the c‐K‐ras2 Gene in Human Colorectal Adenomas with Severe Atypia than in Carcinomas

Human colorectal carcinomas may be induced from adenomas or they may occur de novo. To examine which is the main pathway, we analyzed point mutations at codon 12 in the c‐K‐ras 2 gene in 73 colorectal carcinomas, 13 metastatic tumors, 72 adenomas and 30 normal tissues. The c‐K‐ras 2 codon 12 mutatio...

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Detalles Bibliográficos
Autores principales: Ando, Masayuki, Maruyama, Michio, Oto, Michiei, Takemura, Katsuji, Endo, Mitsuo, Yuasa, Yasuhito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1991
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918406/
https://www.ncbi.nlm.nih.gov/pubmed/1708754
http://dx.doi.org/10.1111/j.1349-7006.1991.tb01836.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918406/
https://www.ncbi.nlm.nih.gov/pubmed/1708754
http://dx.doi.org/10.1111/j.1349-7006.1991.tb01836.x

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