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Higher Frequency of Point Mutations in the c‐K‐ras2 Gene in Human Colorectal Adenomas with Severe Atypia than in Carcinomas
Human colorectal carcinomas may be induced from adenomas or they may occur de novo. To examine which is the main pathway, we analyzed point mutations at codon 12 in the c‐K‐ras 2 gene in 73 colorectal carcinomas, 13 metastatic tumors, 72 adenomas and 30 normal tissues. The c‐K‐ras 2 codon 12 mutatio...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Blackwell Publishing Ltd
1991
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918406/ https://www.ncbi.nlm.nih.gov/pubmed/1708754 http://dx.doi.org/10.1111/j.1349-7006.1991.tb01836.x |