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Structure‐Function Relationships of Microcystins, Liver Tumor Promoters, in Interaction with Protein Phosphatase

Microcystins, isolated from toxic blue‐green algae, are potent inhibitors of protein phosphatases 1 and 2A. Recently, we have reported that mierocystin LR has a potent tumor‐promoting activity on rat liver initiated with diethylnitrosamine. The structure of microcystins is unique in having an unusua...

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Detalles Bibliográficos
Autores principales: Nishiwaki‐Matsushima, Rie, Nishiwaki, Shinji, Ohta, Tetsuya, Yoshizawa, Seiji, Suganuma, Masami, Harada, Ken‐ichi, Watanabe, Mariyo F., Fujiki, Hirota
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1991
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918597/
https://www.ncbi.nlm.nih.gov/pubmed/1657848
http://dx.doi.org/10.1111/j.1349-7006.1991.tb01933.x