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Interaction of the Tumor Inhibitor IKP‐104, a 4(1H)‐Pyridinone Derivative, with Microtubule Proteins
The effects of a mitotic arrestant, IKP‐104, which has an antitumor activity, on the in vitro., polymerization and depolymerization of rat brain microtubules were investigated. IKP‐104 inhibited microtubule polymerization at concentrations greater than 0.71 × 10(‐6)M.,a nd its IC(50) value was deter...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Blackwell Publishing Ltd
1992
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918791/ https://www.ncbi.nlm.nih.gov/pubmed/1556002 http://dx.doi.org/10.1111/j.1349-7006.1992.tb00088.x |