Cargando…
Reduction of MHC-I expression limits T-lymphocyte-mediated killing of Cancer-initiating cells
BACKGROUND: It has been proposed that cancer establishment, maintenance, and recurrence may be attributed to a unique population of tumor cells termed cancer-initiating cells (CICs) that may include characteristics of putative cancer stem cell-like cells. Studies in lung cancer have shown that such...
Autores principales: | Morrison, Brian J., Steel, Jason C., Morris, John C. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918869/ https://www.ncbi.nlm.nih.gov/pubmed/29699516 http://dx.doi.org/10.1186/s12885-018-4389-3 |
Ejemplares similares
-
Histone deacetylase inhibition up-regulates MHC class I to facilitate cytotoxic T lymphocyte-mediated tumor cell killing in glioma cells
por: Sun, Ting, et al.
Publicado: (2019) -
Lung cancer-initiating cells: a novel target for cancer therapy
por: Morrison, Brian J., et al.
Publicado: (2013) -
PBRM1 and the glycosylphosphatidylinositol biosynthetic pathway promote tumor killing mediated by MHC-unrestricted cytotoxic lymphocytes
por: Menasche, Bridget L., et al.
Publicado: (2020) -
Sphere Culture of Murine Lung Cancer Cell Lines Are Enriched with Cancer Initiating Cells
por: Morrison, Brian J., et al.
Publicado: (2012) -
Estimating the In Vivo Killing Efficacy of Cytotoxic T Lymphocytes across Different Peptide-MHC Complex Densities
por: Garcia, Victor, et al.
Publicado: (2015)