Imbalance of Deoxyribonucleoside Triphosphates and DNA Double‐strand Breaks in Mouse Mammary Tumor FM3A Cells Treated in vitro with an Antineoplastic Tropolone Derivative

The mechanism by which α,α‐bis(2‐hydroxy‐6‐isopropyltropon‐3‐yl)‐4‐methoxytoluene (JCI‐3661) kills mouse mammary tumor FM3A (F28–7) cells was studied. When the cells were exposed to the drug at 3.7 μM, the intracellular dNTP pool became unbalanced because of decreases in dGTP and dATP and an increas...

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Detalles Bibliográficos
Autores principales: Yamato, Masatoshi, Hirota, Yasuhide, Yoshida, Sei, Tanaka, Shouhei, Morita, Tetsuo, Sakai, Junko, Hashigaki, Kuniko, Hayatsu, Hikoya, Wataya, Yusuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1992
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918875/
https://www.ncbi.nlm.nih.gov/pubmed/1644668
http://dx.doi.org/10.1111/j.1349-7006.1992.tb00141.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918875/
https://www.ncbi.nlm.nih.gov/pubmed/1644668
http://dx.doi.org/10.1111/j.1349-7006.1992.tb00141.x

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