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High Susceptibility to Lung Cancer Analyzed in Terms of Combined Genotypes of P450IA1 and Mu‐class Glutathione S‐Transferase Genes

Lung cancer is closely associated with cigarette smoking. Aromatic hydrocarbons in smoke, including benzo[n]pyrene, first require metabolic activation by Phase I enzymes, cytochrome P450, to their ultimate forms, and these activated forms are then subjected to detoxification by Phase II enzymes, esp...

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Detalles Bibliográficos
Autores principales: Hayashi, Shinichi, Watanabe, Junko, Kawajiri, Kaname
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1992
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918950/
https://www.ncbi.nlm.nih.gov/pubmed/1399823
http://dx.doi.org/10.1111/j.1349-7006.1992.tb01992.x