Menogaril, an Anthracycline Derivative, Inhibits DNA Topoisomerase II by Stabilizing Cleavable Complexes

Menogaril, an anthracycline derivative, has been shown to possess antitumor activity in experimental animal systems, and is now under phase II clinical studies. However, its mechanism of action has not been elucidated. We have found that it inhibits the decatenation activity of purified DNA topoisom...

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Detalles Bibliográficos
Autores principales: Ono, Katsuhiro, Ikegami, Yoji, Nishizawa, Miwako, Andoh, Toshiwo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1992
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918973/
https://www.ncbi.nlm.nih.gov/pubmed/1331004
http://dx.doi.org/10.1111/j.1349-7006.1992.tb02016.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918973/
https://www.ncbi.nlm.nih.gov/pubmed/1331004
http://dx.doi.org/10.1111/j.1349-7006.1992.tb02016.x

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