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A molecular dynamics study of adenylyl cyclase: The impact of ATP and G-protein binding

Adenylyl cyclases (ACs) catalyze the biosynthesis of cyclic adenosine monophosphate (cAMP) from adenosine triphosphate (ATP) and play an important role in many signal transduction pathways. The enzymatic activity of ACs is carefully controlled by a variety of molecules, including G-protein subunits...

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Detalles Bibliográficos
Autores principales: Frezza, Elisa, Martin, Juliette, Lavery, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918993/
https://www.ncbi.nlm.nih.gov/pubmed/29694437
http://dx.doi.org/10.1371/journal.pone.0196207