Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction

During hemolysis, hemoglobin and heme released from red blood cells promote oxidative stress, inflammation and thrombosis. Plasma haptoglobin and hemopexin scavenge free hemoglobin and heme, respectively, but can be depleted in hemolytic states. Haptoglobin and hemopexin supplementation protect tiss...

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Detalles Bibliográficos
Autores principales: Belcher, John D., Chen, Chunsheng, Nguyen, Julia, Abdulla, Fuad, Zhang, Ping, Nguyen, Hao, Nguyen, Phong, Killeen, Trevor, Miescher, Sylvia M., Brinkman, Nathan, Nath, Karl A., Steer, Clifford J., Vercellotti, Gregory M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919001/
https://www.ncbi.nlm.nih.gov/pubmed/29694434
http://dx.doi.org/10.1371/journal.pone.0196455

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919001/
https://www.ncbi.nlm.nih.gov/pubmed/29694434
http://dx.doi.org/10.1371/journal.pone.0196455

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