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Differential Alterations of Dihydrofolate Reductase Gene in Human Leukemia Cell Lines Made Resistant to Various Folate Analogues
In order to clarify a molecular mechanism of folate resistance in leukemia cells, we studied alterations of the dihydrofolate reductase (DHFR) gene in a human leukemia cell line, MOLT‐3, and its sublines made resistant to methotrexate (MTX), trimetrexate (TMQ) and N(10)‐propargyl‐5,8‐dideazafolic ac...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
1993
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919023/ https://www.ncbi.nlm.nih.gov/pubmed/8449831 http://dx.doi.org/10.1111/j.1349-7006.1993.tb02776.x |