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Differential Alterations of Dihydrofolate Reductase Gene in Human Leukemia Cell Lines Made Resistant to Various Folate Analogues

In order to clarify a molecular mechanism of folate resistance in leukemia cells, we studied alterations of the dihydrofolate reductase (DHFR) gene in a human leukemia cell line, MOLT‐3, and its sublines made resistant to methotrexate (MTX), trimetrexate (TMQ) and N(10)‐propargyl‐5,8‐dideazafolic ac...

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Detalles Bibliográficos
Autores principales:	Miyachi, Hayato, Takemura, Yuzuru, Kobayashi, Hiroyuki, Ando, Kiyoshi, Ando, Yasuhiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 1993
Materias:	Rapid Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919023/ https://www.ncbi.nlm.nih.gov/pubmed/8449831 http://dx.doi.org/10.1111/j.1349-7006.1993.tb02776.x

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