Enhanced Antitumor Activity and Reduced Toxicity of 1,3‐Bis(2‐chloroethyl)‐1‐nitrosourea Administered in Lipid Microspheres to Tumor‐bearing Mice

Stable lipid microspheres (LM) and lipid nanospheres (LN) with average diameters of 200 nm and 50 nm, respectively, were used to encapsulate an lipophilic antitumor agent, 1,3‐bis(2‐chloroethyl)‐1‐nitrosourea (BCNU). LM and LN containing BCNU (lipo BCNU and s‐lipo BCNU, respectively) were prepared b...

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Detalles Bibliográficos
Autores principales: Takenaga, Mitsuko, Igarashi, Rie, Tsuji, Hiroaki, Mizushima, Yutaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1993
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919066/
https://www.ncbi.nlm.nih.gov/pubmed/8226282
http://dx.doi.org/10.1111/j.1349-7006.1993.tb02804.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919066/
https://www.ncbi.nlm.nih.gov/pubmed/8226282
http://dx.doi.org/10.1111/j.1349-7006.1993.tb02804.x

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