Relationship between Development of Diarrhea and the Concentration of SN‐38, an Active Metabolite of CPT‐11, in the Intestine and the Blood Plasma of Athymic Mice Following Intraperitoneal Administration of CPT‐11

Severe diarrhea occurred during daily intraperitoneal administration of 7‐ethyl‐10‐[4‐(l‐piperidino)‐l‐piperidino]carbonyloxycamptothecin (CPT‐11) at a dose of 50 mg/kg in athymic mouse. Serial determination of CPT‐11 and 7‐ethyl‐10‐hydroxycamptothecin (SN‐38), with the use of an on‐line solid extra...

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Detalles Bibliográficos
Autores principales: Araki, Eiji, Ishikawa, Masayuki, Iigo, Masaaki, Koide, Tsutomu, Itabashi, Masayuki, Hoshi, Akio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1993
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919320/
https://www.ncbi.nlm.nih.gov/pubmed/8340259
http://dx.doi.org/10.1111/j.1349-7006.1993.tb02031.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919320/
https://www.ncbi.nlm.nih.gov/pubmed/8340259
http://dx.doi.org/10.1111/j.1349-7006.1993.tb02031.x

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