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Relationship between Development of Diarrhea and the Concentration of SN‐38, an Active Metabolite of CPT‐11, in the Intestine and the Blood Plasma of Athymic Mice Following Intraperitoneal Administration of CPT‐11
Severe diarrhea occurred during daily intraperitoneal administration of 7‐ethyl‐10‐[4‐(l‐piperidino)‐l‐piperidino]carbonyloxycamptothecin (CPT‐11) at a dose of 50 mg/kg in athymic mouse. Serial determination of CPT‐11 and 7‐ethyl‐10‐hydroxycamptothecin (SN‐38), with the use of an on‐line solid extra...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
1993
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919320/ https://www.ncbi.nlm.nih.gov/pubmed/8340259 http://dx.doi.org/10.1111/j.1349-7006.1993.tb02031.x |
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author | Araki, Eiji Ishikawa, Masayuki Iigo, Masaaki Koide, Tsutomu Itabashi, Masayuki Hoshi, Akio |
author_facet | Araki, Eiji Ishikawa, Masayuki Iigo, Masaaki Koide, Tsutomu Itabashi, Masayuki Hoshi, Akio |
author_sort | Araki, Eiji |
collection | PubMed |
description | Severe diarrhea occurred during daily intraperitoneal administration of 7‐ethyl‐10‐[4‐(l‐piperidino)‐l‐piperidino]carbonyloxycamptothecin (CPT‐11) at a dose of 50 mg/kg in athymic mouse. Serial determination of CPT‐11 and 7‐ethyl‐10‐hydroxycamptothecin (SN‐38), with the use of an on‐line solid extraction HPLC system, demonstrated that much higher levels of the compounds are retained in the intestine and the blood plasma after five consecutive daily injections than after a single injection. Histologic examination of the gastrointestinal tract showed hemorrhagic colitis on day 7 and later after five consecutive daily injections of CPT‐11. The direct cause of diarrhea associated with CPT‐11 administration is considered to be enterocolitis caused by high levels of SN‐38 and/or CPT‐11 retained for a long period in the intestine. |
format | Online Article Text |
id | pubmed-5919320 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1993 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-59193202018-05-11 Relationship between Development of Diarrhea and the Concentration of SN‐38, an Active Metabolite of CPT‐11, in the Intestine and the Blood Plasma of Athymic Mice Following Intraperitoneal Administration of CPT‐11 Araki, Eiji Ishikawa, Masayuki Iigo, Masaaki Koide, Tsutomu Itabashi, Masayuki Hoshi, Akio Jpn J Cancer Res Article Severe diarrhea occurred during daily intraperitoneal administration of 7‐ethyl‐10‐[4‐(l‐piperidino)‐l‐piperidino]carbonyloxycamptothecin (CPT‐11) at a dose of 50 mg/kg in athymic mouse. Serial determination of CPT‐11 and 7‐ethyl‐10‐hydroxycamptothecin (SN‐38), with the use of an on‐line solid extraction HPLC system, demonstrated that much higher levels of the compounds are retained in the intestine and the blood plasma after five consecutive daily injections than after a single injection. Histologic examination of the gastrointestinal tract showed hemorrhagic colitis on day 7 and later after five consecutive daily injections of CPT‐11. The direct cause of diarrhea associated with CPT‐11 administration is considered to be enterocolitis caused by high levels of SN‐38 and/or CPT‐11 retained for a long period in the intestine. Blackwell Publishing Ltd 1993-06 /pmc/articles/PMC5919320/ /pubmed/8340259 http://dx.doi.org/10.1111/j.1349-7006.1993.tb02031.x Text en |
spellingShingle | Article Araki, Eiji Ishikawa, Masayuki Iigo, Masaaki Koide, Tsutomu Itabashi, Masayuki Hoshi, Akio Relationship between Development of Diarrhea and the Concentration of SN‐38, an Active Metabolite of CPT‐11, in the Intestine and the Blood Plasma of Athymic Mice Following Intraperitoneal Administration of CPT‐11 |
title | Relationship between Development of Diarrhea and the Concentration of SN‐38, an Active Metabolite of CPT‐11, in the Intestine and the Blood Plasma of Athymic Mice Following Intraperitoneal Administration of CPT‐11 |
title_full | Relationship between Development of Diarrhea and the Concentration of SN‐38, an Active Metabolite of CPT‐11, in the Intestine and the Blood Plasma of Athymic Mice Following Intraperitoneal Administration of CPT‐11 |
title_fullStr | Relationship between Development of Diarrhea and the Concentration of SN‐38, an Active Metabolite of CPT‐11, in the Intestine and the Blood Plasma of Athymic Mice Following Intraperitoneal Administration of CPT‐11 |
title_full_unstemmed | Relationship between Development of Diarrhea and the Concentration of SN‐38, an Active Metabolite of CPT‐11, in the Intestine and the Blood Plasma of Athymic Mice Following Intraperitoneal Administration of CPT‐11 |
title_short | Relationship between Development of Diarrhea and the Concentration of SN‐38, an Active Metabolite of CPT‐11, in the Intestine and the Blood Plasma of Athymic Mice Following Intraperitoneal Administration of CPT‐11 |
title_sort | relationship between development of diarrhea and the concentration of sn‐38, an active metabolite of cpt‐11, in the intestine and the blood plasma of athymic mice following intraperitoneal administration of cpt‐11 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919320/ https://www.ncbi.nlm.nih.gov/pubmed/8340259 http://dx.doi.org/10.1111/j.1349-7006.1993.tb02031.x |
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