Binding Characteristics of (–)‐(R)‐2‐Aminomethylpyrrolidine(1,1‐cyclobutanedi‐carboxylato)‐2‐platinum(II) to DNA, RNA and Protein Molecules in HeLa Cells and Its Lethal Effect: Comparison with cis‐ and trans‐Diammmedichloroplatinums(II)

HeLa S‐3 cells were treated with (195m)Pt‐radiolabeled (–)‐(R)‐2‐aminomethylpyrrolidine(1,1‐cyclobutanedicarboxylato)‐2‐platinum(II) (DWA2114R) under various conditions, and the relationship between the lethal effect of the agent and the number of platinum (Pt) atoms binding to DNA, RNA and proteins...

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Detalles Bibliográficos
Autores principales: Akaboshi, Mitsuhiko, Kawai, Kenichi, Ujeno, Yowri, Takada, Syotaro, Miyahara, Tokiharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1994
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919346/
https://www.ncbi.nlm.nih.gov/pubmed/7508903
http://dx.doi.org/10.1111/j.1349-7006.1994.tb02893.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919346/
https://www.ncbi.nlm.nih.gov/pubmed/7508903
http://dx.doi.org/10.1111/j.1349-7006.1994.tb02893.x

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