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Binding Characteristics of (–)‐(R)‐2‐Aminomethylpyrrolidine(1,1‐cyclobutanedi‐carboxylato)‐2‐platinum(II) to DNA, RNA and Protein Molecules in HeLa Cells and Its Lethal Effect: Comparison with cis‐ and trans‐Diammmedichloroplatinums(II)
HeLa S‐3 cells were treated with (195m)Pt‐radiolabeled (–)‐(R)‐2‐aminomethylpyrrolidine(1,1‐cyclobutanedicarboxylato)‐2‐platinum(II) (DWA2114R) under various conditions, and the relationship between the lethal effect of the agent and the number of platinum (Pt) atoms binding to DNA, RNA and proteins...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Blackwell Publishing Ltd
1994
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919346/ https://www.ncbi.nlm.nih.gov/pubmed/7508903 http://dx.doi.org/10.1111/j.1349-7006.1994.tb02893.x |