Stabilizing the Retromer Complex in a Human Stem Cell Model of Alzheimer’s Disease Reduces TAU Phosphorylation Independently of Amyloid Precursor Protein

Developing effective therapeutics for complex diseases such as late-onset, sporadic Alzheimer’s disease (SAD) is difficult due to genetic and environmental heterogeneity in the human population and the limitations of existing animal models. Here, we used hiPSC-derived neurons to test a compound that...

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Detalles Bibliográficos
Autores principales: Young, Jessica E., Fong, Lauren K., Frankowski, Harald, Petsko, Gregory A., Small, Scott A., Goldstein, Lawrence S.B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919412/
https://www.ncbi.nlm.nih.gov/pubmed/29503090
http://dx.doi.org/10.1016/j.stemcr.2018.01.031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919412/
https://www.ncbi.nlm.nih.gov/pubmed/29503090
http://dx.doi.org/10.1016/j.stemcr.2018.01.031

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