Isolation and molecular characterization of novel glucarpidases: Enzymes to improve the antibody directed enzyme pro-drug therapy for cancer treatment

Repeated cycles of antibody-directed enzyme pro-drug therapy (ADEPT) and the use of glucarpidase in the detoxification of cytotoxic methotrexate (MTX) are highly desirable during cancer therapy but are hampered by the induced human antibody response to glucarpidase. Novel variants of glucarpidase (f...

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Detalles Bibliográficos
Autores principales: Rashidi, Fatma B., AlQhatani, Alanod D., Bashraheel, Sara S., Shaabani, Shabnam, Groves, Matthew R., Dömling, Alexander, Goda, Sayed K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919439/
https://www.ncbi.nlm.nih.gov/pubmed/29698433
http://dx.doi.org/10.1371/journal.pone.0196254

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919439/
https://www.ncbi.nlm.nih.gov/pubmed/29698433
http://dx.doi.org/10.1371/journal.pone.0196254

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