Development and Characterization of Chimeric Anti‐carcinoembryonic Antigen Monoclonal Antibodies and Their Fab Fragments

In an attempt to reduce the immunogenicity of two different murine anti‐carcinoembryonic antigen (CEA) monoclonal antibodies (MAbs), KM10 and A10, we produced recombinant mouse/human chimeric MAbs and the respective Fab fragments carrying the variable regions of the murine MAbs. Chimeric A10 Fab fra...

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Detalles Bibliográficos
Autores principales: Kamigaki, Takashi, Ohyanagi, Harumasa, Yamamoto, Masahiro, Kaneda, Teruo, Goto, Takashi, Ohmura, Takao, Yokoyama, Kazumasa, Saitoh, Yoichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1994
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919441/
https://www.ncbi.nlm.nih.gov/pubmed/8188529
http://dx.doi.org/10.1111/j.1349-7006.1994.tb02097.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919441/
https://www.ncbi.nlm.nih.gov/pubmed/8188529
http://dx.doi.org/10.1111/j.1349-7006.1994.tb02097.x

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