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Effects of Inhibition of O(6)‐Alkylguanine‐DNA Alkyltransferase in Rats on Carcinogenesis by Methylnitrosourea and Ethylnitrosourea
Many alkylating agents are potent carcinogens and there is considerable evidence that the formation of O(6)‐alkylguanine in DNA can lead to mutations and the initiation of neoplastic growth. The repair of O(6)‐methyl‐ or O(6)‐ethylguanine in DNA is known to be brought about by the action of a protei...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Blackwell Publishing Ltd
1994
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919443/ https://www.ncbi.nlm.nih.gov/pubmed/8188519 http://dx.doi.org/10.1111/j.1349-7006.1994.tb02086.x |