Aberrant CYP1A1 Induction: Discrepancy of CYP1A1 mRNA and Aryl Hydrocarbon Hydroxylase Activity in Mutant Cells of Mouse Hepatoma Line, Hepa‐1

We have isolated new benzo[α]pyrene‐resistant clones, cl‐21 and cl‐32, of the mouse hepatoma line, Hepa‐1. CYP1A1‐dependent aryl hydrocarbon hydroxylase activity is not inducible by 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin or 3‐methylcholanthrene in these two cell lines. However, mRNA of CYP1A1 is induci...

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Detalles Bibliográficos
Autores principales: Kikuchi, Hideaki, Usuda, Masahiro, Sagami, Ikuko, Ikawa, Shuntaro, Watanabe, Minro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1994
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919553/
https://www.ncbi.nlm.nih.gov/pubmed/8071113
http://dx.doi.org/10.1111/j.1349-7006.1994.tb02419.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919553/
https://www.ncbi.nlm.nih.gov/pubmed/8071113
http://dx.doi.org/10.1111/j.1349-7006.1994.tb02419.x

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