Site‐specific Mutation of the Human c‐Ha‐ras Transgene Induced by Dimethylbenzanthracene Causes Tissue‐specific Tumors in Mice

Forestoraach squamous cell carcinomas, lung adenocarcinomas and spleen angiosarcomas were induced by dimethylbenzanthracene (DMBA) in the rasH2 transgenic mouse line carrying human c‐Ha‐ras genes with their own promoter, encoding the prototype p21 gene product. Fifteen out of 21 mice (71%) developed...

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Detalles Bibliográficos
Autores principales: Doi, Satoru‐Takahiro, Kimura, Minoru, Katsuki, Motoya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1994
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919566/
https://www.ncbi.nlm.nih.gov/pubmed/7928625
http://dx.doi.org/10.1111/j.1349-7006.1994.tb02951.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919566/
https://www.ncbi.nlm.nih.gov/pubmed/7928625
http://dx.doi.org/10.1111/j.1349-7006.1994.tb02951.x

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