Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice

Genomic analysis of cancer tissues is an essential aspect of personalized oncology treatment. Though it has been suggested that formalin fixation of patient tissues may be suboptimal for molecular studies, this tissue processing approach remains the industry standard. Therefore clinical molecular la...

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Detalles Bibliográficos
Autores principales: Prentice, Leah M., Miller, Ruth R., Knaggs, Jeff, Mazloomian, Alborz, Aguirre Hernandez, Rosalia, Franchini, Patrick, Parsa, Kourosh, Tessier-Cloutier, Basile, Lapuk, Anna, Huntsman, David, Schaeffer, David F., Sheffield, Brandon S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919577/
https://www.ncbi.nlm.nih.gov/pubmed/29698444
http://dx.doi.org/10.1371/journal.pone.0196434

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919577/
https://www.ncbi.nlm.nih.gov/pubmed/29698444
http://dx.doi.org/10.1371/journal.pone.0196434

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