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Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice
Genomic analysis of cancer tissues is an essential aspect of personalized oncology treatment. Though it has been suggested that formalin fixation of patient tissues may be suboptimal for molecular studies, this tissue processing approach remains the industry standard. Therefore clinical molecular la...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919577/ https://www.ncbi.nlm.nih.gov/pubmed/29698444 http://dx.doi.org/10.1371/journal.pone.0196434 |