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Cell-Cycle Modulation of Transcription Termination Factor Sen1

Many non-coding transcripts (ncRNA) generated by RNA polymerase II in S. cerevisiae are terminated by the Nrd1-Nab3-Sen1 complex. However, Sen1 helicase levels are surprisingly low compared with Nrd1 and Nab3, raising questions regarding how ncRNA can be terminated in an efficient and timely manner....

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Detalles Bibliográficos
Autores principales: Mischo, Hannah E., Chun, Yujin, Harlen, Kevin M., Smalec, Brendan M., Dhir, Somdutta, Churchman, L. Stirling, Buratowski, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919780/
https://www.ncbi.nlm.nih.gov/pubmed/29656924
http://dx.doi.org/10.1016/j.molcel.2018.03.010