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Prion protein modulates glucose homeostasis by altering intracellular iron
The prion protein (PrP(C)), a mainly neuronal protein, is known to modulate glucose homeostasis in mouse models. We explored the underlying mechanism in mouse models and the human pancreatic β-cell line 1.1B4. We report expression of PrP(C) on mouse pancreatic β-cells, where it promoted uptake of ir...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919926/ https://www.ncbi.nlm.nih.gov/pubmed/29700330 http://dx.doi.org/10.1038/s41598-018-24786-1 |