GR3027 reversal of neurosteroid-induced, GABA-A receptor-mediated inhibition of human brain function: an allopregnanolone challenge study

RATIONALE: GR3027 is a novel small molecule GABA-A receptor-modulating steroid antagonist, which in non-clinical studies has shown promise for treatment of human disorders due to allosteric over-activation of GABA-A receptors by neurosteroids, such as allopregnanolone. We here studied its safety, ph...

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Detalles Bibliográficos
Autores principales: Johansson, Maja, Månsson, Maria, Lins, Lars-Eric, Scharschmidt, Bruce, Doverskog, Magnus, Bäckström, Torbjörn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919995/
https://www.ncbi.nlm.nih.gov/pubmed/29492615
http://dx.doi.org/10.1007/s00213-018-4864-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919995/
https://www.ncbi.nlm.nih.gov/pubmed/29492615
http://dx.doi.org/10.1007/s00213-018-4864-1

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