Effects of cariprazine on extracellular levels of glutamate, GABA, dopamine, noradrenaline and serotonin in the medial prefrontal cortex in the rat phencyclidine model of schizophrenia studied by microdialysis and simultaneous recordings of locomotor activity

RATIONALE: Aberrant glutamatergic, dopaminergic, and GABAergic neurotransmission has been implicated in schizophrenia. Cariprazine reverses the behavioral effects observed in the rat phencyclidine (PCP)-induced model of schizophrenia; however, little is known about its in vivo neurochemistry. OBJECT...

Descripción completa

Detalles Bibliográficos
Autores principales: Kehr, Jan, Yoshitake, Takashi, Ichinose, Fumio, Yoshitake, Shimako, Kiss, Béla, Gyertyán, István, Adham, Nika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920013/
https://www.ncbi.nlm.nih.gov/pubmed/29637288
http://dx.doi.org/10.1007/s00213-018-4874-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920013/
https://www.ncbi.nlm.nih.gov/pubmed/29637288
http://dx.doi.org/10.1007/s00213-018-4874-z

Ejemplares similares