Identification of the allosteric P2X(7) receptor antagonist [(11)C]SMW139 as a PET tracer of microglial activation

The P2X(7) receptor plays a significant role in microglial activation, and as a potential drug target, the P2X(7) receptor is also an interesting target in positron emission tomography. The current study aimed at the development and evaluation of a potent tracer targeting the P2X(7) receptor, to whi...

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Detalles Bibliográficos
Autores principales: Janssen, Bieneke, Vugts, Danielle J., Wilkinson, Shane M., Ory, Dieter, Chalon, Sylvie, Hoozemans, Jeroen J. M., Schuit, Robert C., Beaino, Wissam, Kooijman, Esther J. M., van den Hoek, Johan, Chishty, Mansoor, Doméné, Aurélie, Van der Perren, Anke, Villa, Alessandro, Maggi, Adriana, Molenaar, Ger T., Funke, Uta, Shevchenko, Rostislav V., Baekelandt, Veerle, Bormans, Guy, Lammertsma, Adriaan A., Kassiou, Michael, Windhorst, Albert D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920098/
https://www.ncbi.nlm.nih.gov/pubmed/29700413
http://dx.doi.org/10.1038/s41598-018-24814-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920098/
https://www.ncbi.nlm.nih.gov/pubmed/29700413
http://dx.doi.org/10.1038/s41598-018-24814-0

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