Long‐term Exposure to the Anti‐inflammatory Agent Phenylbutazone Induces Kidney Tumors in Rats and Liver Tumors in Mice

Long‐term toxicity and carcinogenicity of phenylbutazone, a nonsteroidal anti‐inflammatory drug, were evaluated in F344/N rats and B6C3F1 mice. In 2‐year studies, phenylbutazone was given in corn oil by gavage 5 days per week to groups of 50 rats of each sex at doses of 0, 50, or 100 mg/kg body weig...

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Detalles Bibliográficos
Autores principales: Kari, Frank, Bucher, John, Haseman, Joseph, Eustis, Scot, Huff, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1995
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920813/
https://www.ncbi.nlm.nih.gov/pubmed/7744695
http://dx.doi.org/10.1111/j.1349-7006.1995.tb03048.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920813/
https://www.ncbi.nlm.nih.gov/pubmed/7744695
http://dx.doi.org/10.1111/j.1349-7006.1995.tb03048.x

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